In Alzheimer’s disease, impaired blood flow to brain regions coincides with tau protein buildup. This relationship strengthens as cognition declines, according to new research published in JNeurosci.
Vascular function declines and amyloid-β and tau protein accumulate as Alzheimer’s disease progresses, resulting in neuron death. Like the proverbial chicken and egg, it remains unclear if impaired blood flow causes or is caused by errant protein buildup, or if the two symptoms occur for unrelated reasons.
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