Too much of a good thing—persistent IFNγ depletes progenitor blood cells via BST2

When a person has an infection, the body activates immune responses to fight it. IFNγ is an inflammatory molecule produced by the immune system that helps fight infections. However, long-term exposure to IFNγ has undesirable consequences—it irreversibly exhausts blood stem cells, the progenitors of all blood cells, including immune cells, […]

Researchers identify a rare genetic bone disorder through massive sequencing methods

Researchers of the “Cell Biology and Physiology-LABRET” group of the University of Malaga (UMA), together with the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), have described a new genetic skeletal disorder based on a precision medicine strategy. By using methods of massive sequencing -of all genes- they […]