Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

A German case study recently published in the journal Nature Communications has characterized a long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics in an immunosuppressed kidney transplant recipient and provided evidence for the evolution of SARS-CoV-2 into potentially harmful immune escape mutants during persistent infections. Such escape mutants […]

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

The rapid outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic. Vaccination programs have commenced in many countries around the world and scientists are conducting active research to understand the durability of immune responses post-vaccination. A new study has […]

A review of drugs harmful in COVID-19

In a new study published on the preprint server medRxiv*, researchers investigate a number of drugs that are believed to potentially worsen outcomes in patients with coronavirus disease 2019 (COVID-19). To this end, the researchers used a rapid systematic review and meta-analysis approach to identify and assess any potentially deleterious […]

New methodology for evaluating transmissibility and competitive advantages of co-circulating SARS-CoV-2 variants

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-triggered coronavirus disease 2019 (COVID-19) pandemic began to rage over the world, public health authorities recommended various non-pharmaceutical interventions (NPIs) to reduce viral transmission while vaccines and specific antiviral and antibody-based drugs were developed. However, with the identification of newer SARS-CoV-2 variants […]

Effectiveness of mRNA-1273 against asymptomatic infection, COVID-19 diagnosis, and severe outcomes

A Moderna phase 3 trial in Southern California provides evidence that the RNA-1273 vaccine is highly effective in preventing disease following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Real-World Effectiveness of the mRNA-1273 Vaccine Against COVID-19: Interim Results from a Prospective Observational Cohort Study. Image Credit: […]