New genetic drug target for treatment resistant colorectal cancer

Targeting a specific cancer survival gene in colorectal cancer could lead to new treatment options for advanced disease, new research suggests. Researchers from the Wellcome Sanger Institute, in collaboration with the Candiolo Cancer Institute in Italy and the Netherlands Cancer Institute, used state-of-the-art patient derived organoid models to gather information […]

Drug testing approach uncovers effective combination for treating small cell lung cancer

Researchers from the National Institutes of Health have identified and tested a drug combination that exploits a weakness in small cell lung cancer (SCLC), an aggressive, dangerous cancer. The scientists targeted a vulnerability in how the cancer cells reproduce, increasing already high levels of replication stress—a hallmark of out-of-control cell […]