How cells keep gene silencing in check

Long considered ‘junk,” non-coding RNAs have emerged as important regulators of diverse cellular processes, including the silencing of genes. Working in yeast, researchers from the Bühler group have identified more than 20 mutations that enable RNA-mediated gene silencing. The findings could improve our understanding of the factors that keep gene […]

Scientists map gene changes underlying brain and cognitive decline in aging

Alzheimer’s disease shares some key similarities with healthy aging, according to a new mathematical model described today in eLife. The model provides unique insights into the multiscale biological alterations in the elderly and neurodegenerative brain, with important implications for identifying future treatment targets for Alzheimer’s disease. Researchers developed their mathematical […]

Investigators identify STING gene methylation allows melanoma to evade the immune system

A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma. However, some patients do not show beneficial clinical responses to these novel and very promising immunotherapies. […]

Catalent to Acquire Delphi Genetics and Launch US Plasmid Manufacturing Site to Establish Global pDNA Development and Manufacturing Capabilities

Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products, and Delphi Genetics, a plasmid DNA (pDNA) cell and gene therapy contract development and manufacturing organization (CDMO) based in Gosselies, Belgium, today announced that they have […]

A traditional Chinese medicine could help treat COVID‐19 symptoms

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected in Wuhan, China, in December 2019, causing the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 is a highly transmissible disease that has spread to over 191 countries and territories around the world. To date, 97.61 million cases have […]