Maturation of 'mini brain' organoids matches human brain development

A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived 'mini brain' organoids can mature in a manner that is strikingly similar to human brain development. For the new study, published in Nature Neuroscience February 22, senior authors Dr. Daniel Geschwind of UCLA and Dr. […]

Serial Analysis of Gene Expression (SAGE) and DNA Microarray Compared

Serial analysis of gene expression (SAGE) uses mRNA from a sample to create complementary DNA (cDNA) fragments for amplification and sequencing using high-throughput sequencing technology. Credit: Andre Nantel/ SAGE is based on tags which can identify the original transcript, and rapid sequencing of tags linked together. The procedure essentially simplifies […]

Alzheimer’s Disease | Definition, Causes, Diagnosis & Treatment

Alzheimer’s Disease (AD) is the most common form of dementia worldwide (60-70% of all dementia cases) and is a progressive neurodegenerative disorder. Though around 10-15% of cases are genetic, the vast majority of cases are sporadic and attributed to many risk factors. There is, at present, no cure or disease-modifying […]

Researchers have discovered new links between miscarriage and maternal genes

Researchers at the Estonian Genome Center at the University of Tartu have described hitherto undiscovered associations between miscarriage and maternal genes. They have published their findings in Nature Communications. Miscarriage is the most common complication of pregnancy, affecting about 15% of clinically confirmed pregnancies. Although, the risk of miscarriage increases […]

New prediction algorithm identifies previously undetected cancer driver genes

A new study, led by researchers from the University of California, Irvine, has deepened the understanding of epigenetic mechanisms in tumorigenesis and revealed a previously undetected repertoire of cancer driver genes. The study was published this week in Science Advances. Using a new prediction algorithm, called DORGE (Discovery of Oncogenes […]