SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a primarily respiratory virus. It is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. In severe or critical cases, however, this virus is known to trigger rapid and severe deterioration of multiple organs, including the central nervous system. […]

Mouse monoclonal antibodies protect against SARS-CoV-2 wildtype, UK and South African variants

The importance of cross-neutralizing antibodies to the recently emerged variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is evident in light of the fact that these variants are highly transmissible as well as being able to evade immune responses to earlier variants of this virus. A new preprint […]

Bispecific antibodies neutralize SARS-CoV-2 and its variants

Most research testing monoclonal antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) use antigen probes from plasmablasts and memory B cells from donated plasma of recovered SARS-CoV-2 individuals. However, given the rise of new variants of concern worldwide, the motivation to produce more antibody-based tools against SARS-CoV-2 is […]

Novel polyclonal antibody XAV-19 efficiently neutralizes UK and South African SARS-CoV-2 variants

A promising new study, released as a preprint on the bioRxiv* server, reports on the high neutralizing efficacy of a polyclonal swine antibody against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen responsible for the novel coronavirus disease 2019 (COVID-19). By demonstrating the ability of this antibody to […]

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response

The effect of different neutralizing antibodies, both vaccine-elicited and from convalescent sera, suggests new variants are emerging that can evade the human immune response. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to host cells via its spike protein, which has two parts, the S1 and S2 subunits. The […]

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Their results are currently available on the bioRxiv* preprint […]