Preliminary results to nationwide SARS-CoV-2 molecular testing survey

The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today released the preliminary results of its April 2020 SARS-CoV-2 Testing Survey for clinical laboratories. The anonymous survey was created and administered to document clinical laboratory efforts and experiences. The results will be used to help inform future advocacy and clinical practice programs related to pandemic responses.

AMP’s 67-question survey assessed many important aspects of SARS-CoV-2 molecular diagnostic testing, including methodology, performance, capacity, supply chain, regulatory, and reporting requirements. The preliminary results today included feedback from 118 representatives from US-based academic medical centers, commercial reference laboratories and community hospitals. 85% of these respondents are currently offering SARS-CoV-2 testing to patients, while another 10% are currently in the test validation phase. 90% of the laboratories recognize the need to increase diagnostic testing capacity further, and they are working hard to make this happen in the next few months. However, more than 70% of these laboratories have experienced supply chain interruptions that have resulted in significant delays, in many cases forcing them to validate at least three different diagnostic testing methods at the same time just in case the supply of reagents or materials runs out. These supply shortages have included everything from the RNA extraction kits, primers, probes, and enzymes to the physical sample collection materials, such as the swabs and containers for storage and transportation.

“Clinical laboratories across the country are working hard and being extremely resourceful in order to provide diagnostic SARS-CoV-2 testing to Americans, with the majority running at full staffing/testing capacity seven days a week,” said Karen E. Weck, MD, AMP President and Professor of Pathology and Laboratory Medicine, Professor of Genetics and Director of Molecular Genetics and Pharmacogenomics at University of North Carolina Chapel Hill. “However, AMP members know more testing is needed as the country begins to reopen. We are continuing to deploy multiple testing methodologies to overcome supply shortages, increase capacity and improve turnaround times.”

Based on the common themes found in the survey results, AMP is recommending that federal, state and local governments:

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Fire flowed through my veins: a 14-Year-old mysterious inflammation describes a disease

“He would definitely die,” says his doctor about him. Jack McMorrow, a 14-year-old Boy from New York, made by infection with the Coronavirus – and a mysterious inflammatory disease in children, which may be a Sars-Cov-2 in connection. The “pediatric inflammatory multi-system syndrome (MIS-C) occurs since the beginning of the corona of a crisis significantly more often than before the pandemic. Experts suggest that it is triggered by an Overreaction of the body’s own defenses to the Virus. Instead of protecting the body, the immune system attacks the tissue and organs.

Strong fever, tachycardia, extremely low blood pressure

What it feels like, has James had told his father of the “New York Times” and the news channel CNN. It all started were in mid-April with a slight fever and rashes on the hands. “We have dismissed it,” said John McMorrow. He thought his son might have used to common disinfectants.

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However, in the following ten days it was gone Jack got increasingly worse, writes the New York Times. Symptoms such as Nausea, a swollen throat, dry cough, and a metallic taste had been added. His parents would be consulted via video chat Jacks children’s doctors and on a weekend, even an emergency clinic with him and visited.

Then he woke up one Morning and was motionless

His fever was so high that he “couldn’t move more,” said Jack CNN. “Even if other moving my limbs, it was painful. The only way I could describe it, is that it is almost like electricity or fire, feeling that flowed through my veins.” The “New York Times” said the 14-Year-old, the pain had flooded his body “in a throbbing, stabbing noise”. “You could feel how it flowed through the veins, and it was almost as if someone had injected a direct fire.”

Jack was taken to hospital. He had a tennis ball-sized lymph nodes, high fever, a raging heartbeat and a alarmingly low blood pressure. His resting heart rate was 165 beats per Minute, about twice as high as usual, because his heart is tried, the low blood pressure, which, in turn, oxygen and nutrient supply to vital organs is impaired.

Blood vessels throughout the body become inflamed

Jack had a Form of heart failure called cardiogenic shock, – said the head of the pediatric intensive care of the hospital, Steven Kernie, the New York Times, and Jack’s condition was “quite serious”. The blood vessels in his whole body had been ignited, so that the muscles of the vessels “controlled the flow of blood as well as they should”.

For days the Doctors tried to improve Jack’s health. But it was only when they him, steroids administered, which can have an anti-inflammatory and immunosuppressive effect, they had success. Slowly the Boy recovered.

Meanwhile, Jack is back home. He will have to, for a time, steroids and blood thinners taking, the paper reported. He may have a heart valve cracks, and a residual inflammation of the heart, but the Doctors assumed that this to heal by itself.

Earlier, he had considered time to be an actor, told Jack of the “New York Times”. He even appeared once as an extra on the TV show “Gotham”. But before he became sick, he thought about studying medicine. And the interest in it is now grown. “I just want to make more out of my life, now that I got it back.”

Sources: New York Times, CNN

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