Hardening of the arteries is changed, the heart also in healthy people – natural healing naturopathic specialist portal

Changes in the structure and function of the heart due to atherosclerosis

Even in people without heart weakness, or a past heart attack seems to be a connection between atherosclerosis (hardening of the arteries), and changes in the structure and function of the heart.

In the current investigation, the research group of Professor Dr. Vanessa Xanthakis of the Boston University School of Medicine (BUSM), it was found that even in people without heart failure and myocardial infarction is a connection between calcium deposits in the coronary arteries and changes in the structure and function of the heart seem to be. The results of the study were published in the English journal “PLOS ONE”.

Over 2,600 people were examined for the study

For the current study, it was investigated at 2,650 Participants with an average age of 51 years (48 percent of whom were women), the relationship between the calcification of the coronary arteries and echocardiographic measurements for quantification of these changes in the heart.

Progress of coronary artery progression disease without symptoms?

A deposition of calcium in the coronary arteries (also called atherosclerosis) is a strong predictor for future coronary heart disease. The previous findings suggest that the coronary artery disease with the early development of a heart muscle disease interacts and even progresses when no symptoms are present. There are data about the relationship between coronary calcium in the coronary arteries and echocardiography were missing so far, however, detectable changes in the structure and function of the heart.

Atherosclerosis promotes changes in the heart

The researchers found that higher values of calcification with higher values of the left-mass index and aortic root diameter, interventricular went hand-in-hand, what to do with unwanted impacts, such as changes in the size, shape, structure and function of the heart.

They protect themselves by a healthy lifestyle

“We know that coronary heart disease progresses the heart muscle disease, but these results suggest that there is a direct correlation between the calcium content of the coronary arteries, and structural and functional changes in the heart could give, which underlines the need to lead a healthy life style, in order to prevent calcification of the arteries,” says study author Professor Dr. Vanessa Xanthakis of the Boston University School of Medicine in a press release.

Further research is needed

The expert stressed that further studies were needed to clarify the pathophysiological basis of the observed associations and to assess whether calcium can be used from the coronary arteries for the prediction of changes in the structure and function of the heart. (as)

COVID-19: active ingredient for the treatment in the Test – hope to milder course of Naturopathy naturopathic specialist portal

COVID-19: active ingredient is failure for the treatment of lung tested

In the Wake of the Corona-pandemic in the world is working on strategies to curb the spread of the Virus. Above all, it urgently needs medicines that can be used in particular in severe cases the use. Researchers from Austria have now started the Tests with such a drug.

The development of vaccines against this new Coronavirus is moving forward quickly, however, it is unlikely that these will be available this year. Therefore, it is hoped that it will quicker manage to find drugs to treat already Infected. An Austrian research team is now testing an already developed active substance.

The medium was developed for the treatment of acute respiratory failure

According to a recent communication from the Medical University (MedUni) of Vienna tests in the context of a clinical trial of a potential drug for the treatment of COVID-19.

The data indicate that the synthetic peptide was originally developed for the treatment of acute respiratory failure and is now to be to patients who are suffering from COVID-19, on its effectiveness tested.

Currently, in particular medicinal products that are already approved for a different disease, or at least in development worldwide are tested against Coronavirus-related diseases. Some of these drugs can also cause serious side effects.

Active ingredient approval

As the MedUni Vienna explains, have shown previous clinical data of patients with COVID-19 in the hospital, that 20 percent of the Affected failure acute pulmonary (Acute Respiratory Distress Syndrome, ARDS) suffering, which is often characterised by oedema of the Lungs.

Currently no drug is approved specifically for the therapeutic treatment of pulmonary permeability edema or ARDS.

The new active ingredient Solnatide, one of the Vienna-based company Apeptico GmbH, developed synthetic peptide, is being tested at the MedUni Vienna in the first COVID-19-Concerned.

“The drug has already proven effective in clinical studies for the treatment of lung failure and is on the verge of approval,” explains Markus Zeitlinger, head of the University clinic for Clinical pharmacology of the MedUni Vienna and the Director of studies.

“We are testing this now on a total of 40 subjects with Covid-19, half get the drug, and the other is associated with a Placebo-control group. Our hope is that by the Coronavirus-induced lung diseases with the new drug lighter curves show,“ says the expert.

Possible option for the treatment of severe COVID-19-gradients

The information suggests that the study has been approved, in close coordination with the ethics Commission of the medical University of Vienna, and the authorities accelerated and, together with the University clinic for Clinical pharmacology, University clinic for anesthesia, General carried out in intensive care medicine and pain therapy.

“We are particularly pleased that the year-long preparatory work in this field may be a therapy option in severe cases of Covid-19,” Klaus Markstaller, head of the University Department of anaesthesia, General intensive care medicine and pain therapy.

The active ingredient Solnatide is a synthetic peptide less than 20 amino acids. According to the communication, the expectations from previous clinical investigations are enabled, the directly in the Form of a liquid aerosol in the lower respiratory tract is introduced Solnatide the pulmonary sodium ion channel (ENaC), to enable the Clearance of the Fluid in the pulmonary alveoli directly and to reduce the Leakage of blood and fluids from the capillaries.

To reduce the extent of alveolar Edema and its resolution to accelerate. In addition to this effect Solnatide further complications, which are often observed in the case of lung failure.

Already, a clinical Phase I study in humans, passed

The drug was originally failure for the therapeutic treatment of patients with acute lung and various forms of life-threatening lung permeabilitätsödems (PPO) developed.

To orally inhaled Solnatide was already in a clinical Phase I study in humans, as well as a clinical Proof-of-Concept in a randomized, placebo-controlled, double-blind study (Clinical Phase II trial) and a Phase II pilot study in patients with pneumonia, Sepsis, ARDS, primary graft dysfunction and other causes of life-threatening Pulmonary dysfunction.

“Should be the active ingredient successfully, we rely on a fast-track approval process by the regulatory authorities,” says Zeitlinger. (ad)