Key stem cell dormancy mechanism discovered

Princess Margaret Cancer Centre researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers. The team has made the discovery by performing a deep mechanistic study of lysosomes, which […]

Engineered ‘off the shelf’ stem cells target breast cancer that metastasizes to the brain

Approximately 15-to-30 percent of patients with metastatic breast cancer have brain metastasis (BM), with basal-like breast cancer (BLBC) metastasizing to the brain most frequently. The prognosis for BLBC-BM patients is poor, as the blood-brain barrier prevents most therapeutics from reaching the brain. Testing candidate therapies in clinical trials is also […]

Designer DNA therapeutic wipes out cancer stem cells, treats multiple myeloma in mice

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That’s in part because cancer stem cells drive the disease—cells that continually self-renew. If a therapy can’t completely destroy these malignant stem cells, the cancer is likely to keep coming back. Researchers […]